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A counteracting agent may be the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide per-orally active (12-15) that may also affect many central disturbances (16-23), efficient in inflammatory bowel disease trials (PL 14736) (24, 25) and various wound treatment (26-28), no toxicity reported (12, 13, 24, 25)) which showed various hepatoprotective effects (29-31)

as a result, subcutaneous injections and intranasal delivery are the predominant methods used in research, though both routes present practical challenges for routine clinical use

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At our clinic, the joint pain patients who see the most benefit from BPC-157 are those with chronic knee, shoulder, or hip pain that has plateaued after standard orthopedic treatment, particularly where inflammatory load is a significant component of the symptom picture